Chemical structure of apixaban
WebSep 24, 2024 · Pyridine & Pyrimidine. Pyridine is an example of a six-membered aromatic heterocycle and has an electronic structure similar to benzene. In the bonding picture of pyridine the five carbons and single nitrogen are all sp 2 hybridized. All six of these atoms have a p orbital perpendicular to the plane of the ring and each contains one pi electron … WebEribaxaban 78 ( 38, Fig. 9) is a D-proline-based FXa inhibitor which incorporates a chlorophenyl P1 in combination with a fluorophenylpyridinone P4 group and has a …
Chemical structure of apixaban
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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. Apixaban has no direct effect on platelet aggregation, but by inhibiting factor Xa, it indirectly decreases clot formation induced by thrombin. Web[Table, CHEMICAL FORMULA AND STRUCTURE]. - LiverTox - NCBI Bookshelf Browse Titles Advanced LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Show details Drug Records From: Apixaban Copyright Notice Drug Records Views Cite this Page PDF version of this page (97K) Bulk Download Bulk download …
WebChemical Formula C 13 H 18 Cl 2 N 2 O 2 Synonyms L-PAM L-Phenylalanine mustard L-Sarcolysine Melfalano Melphalan Melphalanum p-L-Sarcolysin Phenylalanine mustard Phenylalanine nitrogen mustard External IDs CB 3025 CB-3025 NCI-C04853 NSC-241286 NSC-8806 SK 15673 SK-15673 Pharmacology Indication WebOct 11, 2024 · Apixaban is a novel oral anticoagulant (NOAC) approved by the US Food and Drug Administration (FDA) in 2012 for use in patients with non-valvular atrial fibrillation to reduce the risk of stroke and blood clots. …
WebMar 18, 2024 · To enable computational design of binders, we developed a unit of protein structure-a van der Mer (vdM)-that maps the backbone of each amino acid to … WebNov 1, 2024 · Apixaban (CAS Reg. No. 503612-47-3; chemical structure, Fig. 1) is aa selective, oral, reversible inhibitor of coagulation factor Xa [13], [14] which has been …
WebApixaban is then broadly known as an anticoagulant blood thinner. More specifically, however, it should be classed as an oral, direct, selective, and reversible factor Xa inhibitor. In other...
WebNov 1, 2016 · Design, synthesis, and structure-activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 … basrikron spawn timerWebVisit ChemicalBook To find more Apixaban Impurity 16(1619934-76-7) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Apixaban Impurity … basri ket mtgWebThe sequence of monosaccharides is D-GlcNS6S-α- (1,4)-D-GlcA-β- (1,4)-D-GlcNS3,6S-α- (1,4)-L-IdoA2S-α- (1,4)-D-GlcNS6S-OMe, as shown in the following structure: References [ edit] ^ Walenga JM, Jeske WP, Fareed J (2005). "Biochemical and Pharmacologic Rationale for Synthetic Heparin Polysaccharides". taka one ok rock igWebApixaban appears as a white-to-pale yellow, non-hygroscopic crystalline powder, with an aqueous solubility of 0.028 mg/mL at 24°C. The reported methods of estimation of … basri lenjaniWebDescribe what kind of drug apixaban is, in both a broad and specific sense. Recognize true and false statements about apixaban. Name atoms found in the chemical structure of … taka/one ok rockWebApixaban is an anticoagulant used to treat venous thromboembolic disorders. The present work describes the origin and synthesis of related substances of Apixaban PG ester-1 and PG ester-2. These impurities arise in the process of Apixaban drug substance, later these impurities are transformed into the final Apixaban drug substance. basril tariganWebChemical Class: A pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted … taka one ok rock insta