WebChlorothiazide is a weakly acidic drug with a pKa of 6.5. If administered orally, at which of the following sites of absorption will the drug be able to readily pass through the membrane? A. Mouth (pH approximately 7.0). B. Stomach (pH of 2.5). C. Duodenum (pH approximately 6.1). D. Jejunum (pH approximately 8.0). E. Ileum (pH approximately 7.0). WebChlorothiazide C7H6ClN3O4S2 - PubChem compound Summary Chlorothiazide Cite Download Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical Properties 4 Spectral Information 5 …
Hydrochlorothiazide: Package Insert - Drugs.com
WebSep 3, 2024 · Chlorothiazide is not metabolized but is eliminated rapidly by the kidney; 96 percent of an intravenous dose is excreted unchanged in the urine within 23 hours. The … Note:The manufacturer states that IV and oral dosing are equivalent. Some clinicians may use lower IV doses; however, because of chlorothiazide's poor oral absorption. Hypertension:Oral: 500 to 2,000 mg daily divided in 1 to 2 doses Edema:Oral, IV: ACCF/AHA 2013 heart failure guidelines: Oral: 250 to 500 mg once … See more Note:Although the manufacturer states that IV and oral dosing are equivalent; some clinicians use lower IV doses due to the poor oral absorption. Edema (diuresis), heart failure, … See more IV: Do notadminister injection via IM or SubQ route. Administer slowly by direct IV injection or infusion; avoid extravasation of parenteral solution … See more Powder for injection: To reconstitute, add SWFI 18 mL to make 28 mg/mL. May be further diluted with dextrose or sodium chloride solutions. See more A 50 mg/mL oral suspension may be made with tablets. Crush ten 500 mg chlorothiazide tablets in a mortar and reduce to a fine … See more high waisted tie up pants
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WebHydrochlorothiazide has an onset of action within 2 hr, peaks at 4 hr, and lasts 12 hr. Drug Interactions and Toxicity: Drug interactions include a decrease in efficacy of anticoagulants and insulin and an increase in efficacy of digoxin, loop diuretics, vitamin D, … WebMar 1, 2024 · Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine which helps lower the blood pressure. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet From Mayo Clinic to your inbox WebConcentrations of hydrochlorothiazide are 1.6 to 1.8 times higher in whole blood than in plasma. Binding to serum proteins has been reported to be approximately 40% to 68%. The plasma elimination half-life has been reported to be 6 to 15 hours. Hydrochlorothiazide is eliminated primarily by renal pathways. sma syndrome in adults