WebJun 21, 2024 · FOXM1 expression is elevated in small cell lung cancer cells in vitro and in vivo While FOXM1 regulates cell proliferation and is correlated to many cancer types, its mechanisms of action in... To examine the signal transduction pathways involved in the CYP26A1-mediated apoptotic resistance, we used various specific kinase inhibitors. An MAPK inhibitor (PD98059) significantly restored sensitivity to anoikis, which was suppressed by CYP26A1, whereas other inhibitors such as a p38 MAPK inhibitor … See more Several investigators have revealed that deregulated overexpression of CYP26A1 could be detected in a number of cancer cell types, including breast carcinomas (Sonneveld et al., … See more To deplete cells of RA in vitro, we generated two independent CYP26A1 constitutively overexpressing pools of AC2M2 cells, a … See more We next evaluated the ability of tumor cells to grow under anchorage-independent growth conditions, a measure of cell … See more Evasion of apoptosis is a hallmark of cancer and resistance to anoikis (apoptosis resulting from loss of cell–matrix interaction) may be a predominant contributor to neoplastic progression (Evan … See more
A novel role for the retinoic acid-catabolizing enzyme …
WebMar 22, 2024 · Lung cancer often spreads (metastasizes) to other parts of the body, such as the brain and the bones. Cancer that spreads can cause pain, nausea, headaches, or other signs and symptoms … WebSep 15, 2010 · Abstract. All-trans retinoic acid (RA) is a critical signaling molecule and its concentration is tightly regulated. Several P450 enzymes including CYP26A1, CYP2C8, … pssap early release of super form
Tissue expression of CYP26A1 - Summary - The Human Protein …
WebNational Center for Biotechnology Information WebFeb 15, 2011 · CYP24A1 is overexpressed in many cancers and encodes the enzyme that catabolizes 1,25-D 3. The purpose of our study was to assess CYP24A1 as a prognostic … WebNational Center for Biotechnology Information horsham fatface