Web3 aug. 2024 · The hepatocyte reprogramming was under tight cooperative control of a network of fibrosis-activated transcription factors, as exemplified by the transcription … Web25 okt. 2024 · Reprogramming cells to treat liver disease Coaxing liver cells to revert to a less differentiated form is opening up the potential for damaged liver treatment. Produced …
Lineage Reprogramming: A Promising Way to Generate …
Web27 feb. 2014 · Highlights. •. FOXA3, HNF1A, and HNF4A convert human fibroblasts to hepatocyte-like cells. •. hiHep cells display functions of mature hepatocytes, including … Web15 nov. 2024 · Patient derived cells can be reprogrammed to iPSCs, expanded, and differentiated, thereby providing a limitless supply of disease specific hepatocytes. Here, … simons car shop
Liver-fibrosis-activated transcriptional networks govern hepatocyte ...
Web12 aug. 2024 · This approach relies on the overexpression of three hepatocyte nuclear factors ( HNF1A, HNF6, and FOXA3) in combination with different nuclear receptors … Web18 sep. 2024 · With great interest, we read the article written by Kim et al. in a recent issue of Journal of Hepatology. 1 The authors developed a successful HAC culture system for … Web4 dec. 2024 · SIGNIFICANCE We evaluated the clinical relevance of hepatocyte-driven ICC model and revealed critical but distinct roles of YAP1 and SOX9 in AKT-NICD-driven … simon scarrow waterstones