Mrtfa とは
WebMay 15, 2024 · Identification of signaling pathways regulating obesity-induced adipose tissue fibrosis has therapeutic potential. Lin et al. show that myocardin-related transcription factor A (MRTFA) drives the recruitment of fibrogenic progenitor cells (FPCs) at the expense of healthy adipocytes. MRTFA-deficient mice are protected from chronic diet-induced … WebAug 16, 2024 · RNA sequencing of Mrtfa –/– dendritic cells showed a reduction in cholesterol metabolism when compared with wild-type cells 114, possibly connecting mechanotransduction and cholesterol metabolism.
Mrtfa とは
Did you know?
WebApr 9, 2024 · The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is … WebThe mouse MRTF-A gene, located on chromosome 15, contains 14 exons distributed across 37 kb of DNA. To introduce a loss-of-function muta- tion in the gene, we deleted a 1.7-kb region encompassing ...
WebJun 14, 2011 · Subcellular localization of the actin-binding transcriptional coactivator MRTF-A is controlled by its interaction with monomeric actin (G-actin). Signal-induced decreases in G-actin concentration reduce MRTF-A nuclear export, leading to its nuclear accumulation, whereas artificial increases in G-act … WebMar 4, 2024 · KIAA1438 encodes a predicted 934-amino acid protein. RT-PCR analysis detected expression of KIAA1438 in all tissues tested, with relatively low levels in …
WebAug 19, 2024 · We also noticed that the nuclear signal of MRTFA appears to be more intense in livers with advanced fibrosis (stage 3/4) than those with early-stage fibrosis (stage 1/2) (Figures 1G and 1H). Together, these results suggest that MRTF-cytoskeleton activation is a molecular hallmark of liver cirrhosis, which is also consistent to previous reports ... WebNov 2, 2024 · Interestingly, a series of mutants of MKL1/MRTFA uncovers the functional domains of MKL1/MRTFA, which were used to generate dominant negative mutants (Miralles et al., 2003). Because the basic 1 (B1) and basic 2 (B2) domains are required for the nuclear import of MKL1/MRTFA, the deletion of these two domains (ΔB1B2) inhibits …
Webmouse, rat と human 由来のMRTF-A WB, IP, IF と ELISAでの検出にはお勧めします ... MRTF-A Antibody (G-7) is an IgM κ mouse monoclonal MRTF-A antibody (also …
WebA gene on chromosome 10q21 that encodes a transcription factor which activates mitochondrial transcription and participates in mitochondrial genome replication. … husky 7high cabinetWebMar 21, 2024 · GeneCards Summary for MRTFA Gene. MRTFA (Myocardin Related Transcription Factor A) is a Protein Coding gene. Diseases associated with MRTFA … maryland state tax underpayment penaltyWebMar 5, 2024 · A mouse model of AD was created by continuous infusion of angiotensin II (AngII) that induced MRTF-A expression and caused Aortic dissection (AD) in 4 days. Systemic deletion of Mrtfa gene resulted in a marked suppression of AD development. the ITGA5-MRTFA pathway is a potential target to ameliorate obesity-associated metabolic … husky 77 inch shelvingWebJan 1, 2024 · MRTFA contains two regions enriched for basic residues (e.g., lysine and arginine), located on either side of RPEL3.The first basic domain, encoded by exon 7 … husky 72 tool cabinetWebMay 15, 2024 · Because MRTFA is a major regulator of fibrosis in various tissues including the skin, lung, heart, and eye (Shiwen et al., 2015, Sisson et al., 2015, Small et al., 2010, Yu-Wai-Man et al., 2014), we investigated whether its deficiency also protects adipose tissue from chronic diet-induced fibrosis and associated inflammation.Collagen fiber … maryland state tax withholding form 2023WebWant to thank TFD for its existence? Tell a friend about us, add a link to this page, or visit the webmaster's page for free fun content. Link to this page: maryland state tax statusWebNov 10, 2024 · d, Immunoblot of MRTFA for untreated muscles (Immo) and mechanically stimulated muscles (MS). e, Fluorescence images of MRTFA in muscle tissues treated with and without mechanical stimulation ... husky 77 piece ratcheting tap and die set