2024 Myc and atf4

Myc and atf4

Author: nozh

August undefined, 2024

Web1 jul. 2024 · Subsequently, ATF4 co-occupies promoter regions of over 30 MYC target genes, primarily those regulating amino acid and protein synthesis, including 4E-BP1, a negative regulator of translation. 4E-BP1 is essential to balance protein synthesis, relieving MYC-induced proteotoxic stress. 4E-BP1 activity is negatively regulated by mTORC1 … Web8 feb. 2024 · In turn, elevated c-MYC supports ATF4 translational induction by enhancing the expression of the amino acid transporter SLC7A5, increasing the uptake of essential …

ATF4 regulated by MYC has an important function in anoikis …

Web1 mrt. 2024 · While ATF4 is a major downstream effector of the ISR, evidence has emerged that ATF4 can also be activated by pro-growth signals that stimulate mTORC1 signaling ( Adams, 2007; Ben-Sahra et … Web5 jan. 2024 · While not as widely studied in the context of amino acid restriction as ATF4, c-MYC has emerged as an important regulator of glucose and glutamine metabolism in cancer cells. c-MYC supports non-oxidative glucose metabolism through transcriptional upregulation of glucose transporter GLUT1, multiple glycolytic enzymes, and the lactate … askjillian twitter

Full article: Solanine Represses Gastric Cancer Growth by …

Web7 feb. 2024 · Citation 45 Recently, MYC signaling was demonstrated to be regulated by AAMDC, an oncogene that controls the translation of MYC and ATF4. Citation 16 This finding was verified in our study, as evidenced by solanine-induced AAMDC downregulation resulting in the deactivation of the MYC-ATF4-Sesn2 pathway in nude mice and gastric … Web20 apr. 2024 · Notably, GCN2-eIF2α-ATF4 activation by MYC was recently described. By generating excess uncharged tRNAs, c-Myc induces an optimal expression of ATF4. … Web12 okt. 2015 · ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation. J Pathol 2015; 235 : 90–100. Article CAS … askjillian

MAPK signaling regulates c-MYC for melanoma cell adaptation to ...

Myc and atf4

The Chemical Biology of Ferroptosis in the Central Nervous System

Web1 aug. 2024 · In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) … Web21 aug. 2014 · Mechanistically, we identified ATF4 as a novel regulator which coordinates with N-Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which correlates with that of N-Myc and ATF4, is markedly elevated in high-stage neuroblastoma tumour samples compared with low-stage ones.

Did you know?

Web13 nov. 2012 · ATF4 then activates PUMA and other genes (e.g., NOXA and TRB3) involved in the execution of cell death, sensitizing tumor cells to Myc-mediated apoptosis. Like … Web22 aug. 2024 · Further studies revealed that MYC had a transcriptional effect on MTHFD2 and was also regulated by ATF4. PCR, and western blotting experiments with ATF4 …

Web1 jul. 2024 · Inhibition of mTORC1 signalling can rescue ATF4-deficient cells from MYC-induced ER stress. Acute deletion of ATF4 significantly delays MYC-driven tumour progression and increases survival in mouse models. 105 Moreover, compared with normal tissues, the activation/overexpression of GCN2 and the increase in phosphorylated … Web26 dec. 2024 · Elevated EAAs, in turn, stimulate Myc mRNA translation, in part through attenuation of the GCN2-eIF2α-ATF4 amino acid stress response pathway, leading to …

Web7 feb. 2024 · Importantly, they found that the SGOC enzyme genes are also direct transcriptional targets of ATF4. More specifically, in MYCN-amplified NB, both MYCN and ATF4 are the essential for ... Web12 okt. 2015 · Other recent data has shown that ASCT2 is not only regulated by ATF4, but also by N-Myc, 42, 43 adding to the well described role of c-Myc in transcriptionally regulating glutamine metabolism. 44 ...

Web2 nov. 2024 · SiRNA of MYC, ATF4, or DDIT3 significantly reduced the expression of Gln metabolic genes in WT cells . Established Myc targets involved in glycolysis, lipid, or …

Web18 sep. 2015 · The transcription factor MYC upregulates and downregulates distinct sets of target genes, ... ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. ask jenni aiWebMechanistically, we identified ATF4 as a novel regulator which coordinates with N-Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which correlates with … ask jesse kellyWeb1 jan. 2015 · A systemic glutamine influx analysis identifies that MYCN‐amplified neuroblastoma cells predominantly rely on activation of ASCT2 to maintain sufficient levels of glutamine essential for the TCA cycle anaplerosis, and elucidate a novel mechanism depicting how cell autonomous insults (MYCN amplification) and microenvironmental … askjimmysmithWeb11 jul. 2024 · 结果显示，atf4表达降低后，myc的活化造成蛋白质在肿瘤细胞内不断堆积，代谢压力激增。最终，肿瘤细胞死于内部应激过强。而在淋巴癌小鼠肿瘤模型中，研究团 … ask jessWeb图片来源：新浪财经起因是7月1日，著名科学杂志《自然》的子刊《Nature Cell Biology》刊登了一篇论文，文中描述了一种臭名昭著而又让人束手无策的原癌基因——MYC和它的“好搭档”ATF4，如何被研究人员成功“拆散”、并且最让癌细胞终走向自我毁灭的过程。. MYC是一种早已明确的强大原癌基因 ... lake hydraulics ask jimmy pte ltdWeb8 okt. 2024 · ATF4 is a crucial transcription factor in the integrated stress response, a major adaptive signaling pathway activated by tumor microenvironment and therapeutic … ask jillie