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The lysosomal rag-ragulator complex

Splet25. jun. 2024 · A genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen to uncover mediators of caspase-8-dependent pyroptosis identified an … Splet24. jun. 2024 · 进一步研究发现Rag-Ragulator的功能缺失能够显著抑制complex Ⅱ的形成、RIPK1磷酸化和caspase-8激活，提示Rag-Ragulator作用于complex Ⅱ上游。 功能结构域Mapping实验结果显示RagC分别与RIPK1蛋白N端kinase domain和caspase-8蛋白C端caspase domain相互作用。

(PDF) The Rag-Ragulator Complex Regulates Lysosome

Splet28. jun. 2024 · The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. 星级： 14 页. RIPK1 suppresses apoptosis mediated by TNF and … SpletThe RRAG heterodimer is tethered to the lysosomal surface by a pentameric protein complex called Ragulator, which is composed of LAMTOR1 to LAMTOR5. ... Intriguingly, … fahrrad service station wien https://yangconsultant.com

The Rag-Ragulator Complex Regulates Lysosome Function and …

Splet12. sep. 2024 · The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy. The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) is unique in its mTORC1 substrate recruitment mechanism, which is strictly dependent on the amino-acid-mediated activation of the RagC GAP FLCN. TFEB … Splet19. maj 2024 · The Rag GTPase heterodimer does not contain any lipidation motif, and its lysosomal localization is dictated by Ragulator (Figure 1 A; Bar-Peled et al., 2012; Sancak … SpletThe Rag-Ragulator complex is a central regulator of lysosomal activity Summary Microglia are resident macrophages of the CNS that are essential for phagocytosis of apoptotic … fahrradservice winkler

刘星团队等揭示耶尔森菌诱导细胞焦亡关键机制 病原体 病原菌 免 …

Category:The Rag-Ragulator Complex Regulates Lysosome Function and …

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The lysosomal rag-ragulator complex

[PDF] Ragulator-Rag Complex Targets mTORC1 to the Lysosomal …

Splet07. jul. 2024 · The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth in eukaryotic cells. The active mTORC1 promotes cellular anabolic processes including protein, pyrimidine, and lipid biosynthesis, and inhibits catabolic processes such as autophagy. Consistent with its growth-promoting functions, hyper … http://shanghaipasteur.cas.cn/zhxw/202406/t20240624_6715152.html

The lysosomal rag-ragulator complex

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SpletLysosomal Diseases. Encyclopedia of Cell Biology 2024. [DOI: ... Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature 2024;614:572-9. ... Murphy LO. GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis.. [DOI: 10.1101/2024.02.22.432209] [Cited by in … http://www.bio-review.com/rag-ragulator/

Splet25. jan. 2024 · 美国加州大学伯克利分校James H. Hurley等研究人员合作揭示溶酶体mTORC1–TFEB–Rag–Ragulator巨型复合物的结构。. 相关论文于2024年1月25日在线发 … Splet25. jun. 2024 · More information: Zengzhang Zheng et al, The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia, Science …

Splet25. jun. 2024 · The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Zhang CS et … Splet24. jun. 2024 · 验证实验结果显示Rag-Ragulator复合物特异性地参与TLR/TNF-caspase-8-GSDMD通路介导的细胞焦亡，而不参与经典或非经典炎症小体介导的细胞焦亡。 进一步 …

Spletscientific article published on 6 January 2016

Splet2024年6月25日，中国科学院上海巴斯德研究所刘星团队等人在Science 在线发表题为The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis … doghouse teaneck njhttp://shanghaipasteur.cas.cn/zhxw/202406/t20240624_6715152.html dog houses with porch and windowsSplet10. apr. 2024 · The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia; RIPK1 activates distinct gasdermins in macrophages … doghouse teaneckSplet25. jan. 2024 · The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy 1.The phosphorylation of TFEB by the mechanistic target of rapamycin … fahrrad service station bad cannstattSpletWe show that RagA and Lamtor4, two components of the Rag-Ragulator complex, are essential regulators of lysosomes in microglia. In zebrafish lacking RagA function, … doghouse teasdog house tavern langley waSpletThe Ragulator-Rag complex is a regulator of lysosomal signalling and trafficking in eukaryotic cells, which plays an important role in regulating cell metabolism and growth … dog house tecumseh mi