WebAug 8, 2024 · An evaluation of the construction and biological potential of thieno[3,2-b]thiophene–chalcone, a chalcone derivative attached to a thiophene scaffold, was reported. Compounds 210 – 213 recorded excellent antibacterial effect toward S. aureus (ZI = 24, 23, 22, and 22 mm, respectively), which was more active than ampicillin (ZI = 20 … WebAll the newly synthesized chalcone derivatives were examined for their in vitro antiproliferative inhibitory activity using, A-375, MCF-7, A-549, HT-29, and H-460 human cancer cell lines. Cisplatin and foretinib were used as a positive control.
Synthesis of Chalcones Derivatives and Their Biological Activities: …
Webchalcones into pyrazoline derivatives can dramatically increase their biological properties such as antibacterial [7], antiprotozoal [8], or anti-inflammatory [9] activities. On the basis of these aspects we have synthesized a novel pyrazoline-based chalcone from 3-acetyl-2,5-dimethylthiophene and 3,5-dimethyl-1-phenylpyrazole-4-carboxaldehyde. WebThe fluoro-substituted tris-chalcone derivatives were synthesized from phloroglucinol and benzaldehyde in three steps (Scheme 1) [5]. The tris-chalcones have shown inhibition of hCA I and II isoenzymes, acetylcholinesterase, butyrylcholinesterase. The base-catalyzed Claisen- Schmidt condensation reaction between aromatic aldehydes and ketones ... blaser arthur
An efficient protocol for the synthesis of novel hetero-aryl chalcone …
WebDec 6, 2024 · PDF Tools Share Graphical Abstract α-Substitution of chalcones has a direct effect on their reactivity as Michael acceptors and hence on their biological activities; therefore, it is a promising approach to tune the reactivity and bioactivity of chalcones. Web2.1.2 General synthesis of the thiophene-based heterocyclic chalcone derivatives All compounds as shown in Figure 1 have been synthesized following the procedures described herein. The thiophene based-heterocyclic chalcone derivatives, 2,4,5-OMe@Chal, 2,4,6-OMe@Chal and 3,4,5-OMe@Chal were prepared through the WebThiophene-derived compounds are interesting in chemistry, biology and pharmacology because of their various pharmacological activities. Complex compounds with metals have also been prepared and studied. It is stated that the structure and conformation of the molecule significantly alter the biological activities [1]. blaser 6.5 creedmoor for sale